Optimization of Atropine Extraction Process from Atropa Belladonna by Modified Bubble Column Extractor with Ultrasonic Bath
نویسندگان
1 Institute of Medicinal Plants, ACECR, Karaj, Iran
2 School of Chemical Engineering, College of Engineering, University of Tehran, P.O. Box 11155-4563 Tehran, I.R. IRAN
3 School of Chemical Engineering, University College of Engineering, University of Tehran, I.R. IRAN
4 Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, P.O. Box 31375-369 Karaj I.R. IRAN
doi
10.30492/ijcce.2016.23556چکیده
Modified Bubble Column Extraction with Ultrasonic Bath (BCE-UB) method was used to extract atropine from the stem and leaves of Atropa belladonna. Optimum condition were obtained with Kamada solvent which was chloroform-methanol-ammonia 15:15:1(v/v/v) as extraction solvent, the particle size of less than 350 µm, an extraction time of 23.95 min, a liquor to material ratio of 15.08 mL/g and an air flow of 6.31 mL/min.g. In this state, percent of extracted atropine was calculated which was equal to 6.81%. Percent of extracted atropine was 6.31% that showed a little difference compared to the predicted value. In order to study the effect of bubbles on the extraction rate, the same extraction with the previous method was performed in a stirred tank. Percent of atropine was 5.59%.
