Synbiotic Supplementation Improves Metabolic Factors and Obesity Values in Women with Polycystic Ovary Syndrome Independent of Affecting Apelin Levels: A Randomized Double-Blind Placebo-Controlled Clinical Trial
نویسندگان
1 Student’s Research Committee, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
2 Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
doi
10.22074/ijfs.2021.6186چکیده
Background: This research investigated the symbiotic supplement influences on serum glycemic indices and lipidsas well as apelin rates and obesity values in polycystic ovary syndrome (PCOS) patients.Materials and Methods: A total of 68 obese or overweight patients (20-44 years old) with PCOS were enrolled toconduct a randomized double-blinded placebo-controlled clinical trial. A total of 34 people in the synbiotic group receiveda synbiotic supplement and 34 people in the placebo group received placebo, daily for 8 weeks. Fasting bloodspecimens, anthropometric measurements and dietary intake data were gathered three times during the study. Theinformation was analyzed by independent t test, paired t test, analysis of covariance and chi-square test.Results: Synbiotic supplementation significantly decreased serum fasting glucose (P=0.02), insulin (P=0.001), homeostaticmodel assessment for insulin resistance (IR, P=0.001), weight (P=0.02), body mass index (BMI, P=0.02),waist circumference (WC, P=0.01), hip circumference (HC, P=0.02), and waist-to-height ratio (WHtR, P=0.02) butsignificantly increased high-density lipoprotein (HDL) cholesterol (P=0.02) compared to the placebo. At the end of thetrial, no significant differences were seen in serum total cholesterol, triglyceride (TG), low-density lipoprotein (LDL)cholesterol, or apelin levels as well as waist-to-hip ratio (WHR) between the two groups. Conclusion: Synbiotic supplementation improved glycemic indices, lipid profile and obesity values in womenwith PCOS. These beneficial effects were not related with alterations in serum apelin levels (Registration number:IRCT20100408003664N19).
