Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome
نویسندگان
1 Department of Obstetric and Gynecology, Dumlupınar University Medical Faculty Hospital , Kütahya, Turkey
2 5Department of Internal Medicine, Fatih University Medical Faculty Hospital, Ankara, Turkey
3 Department of Obstetric and Gynecology, Nenehatun Women Health Hospital, Erzurum, Turkey
4 4Department of Internal Medicine, Erzurum Bölge Training and Research Hospital, Erzurum, Turkey
5 Department of Urology, Palandöken Hospital, Erzurum, Turkey
6 Department of Obstetric and Gynecology, Dumlupınar University Medical Faculty Hospital , Kütahya, Turkey
7 Department of Obstetric and Gynecology, Nenehatun Women Health Hospital, Erzurum, Turkey
8 4Department of Internal Medicine, Erzurum Bölge Training and Research Hospital, Erzurum, Turkey
doi
10.22074/ijfs.2015.4238چکیده
Background We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. Materials and Methods In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinol- ogy Outpatient Clinic, Erzurum Training and Research Hospital, Erzurum, Turkey, from December 2010 to January 2011. GFRs were estimated by Modification of Diet in Renal Disease (MDRD) formula. CRP, urinary albumin excretion (UAE) and uric acid levels were also measured. Results GFRs were significantly higher in PCOS group than control (135.24 ± 25.62 vs. 114.92 ± 24.07 ml/min per 1.73 m2). CRP levels were significantly higher in PCOS patients (4.4 ± 3.4 vs. 2.12 ± 1.5 mg/l). The PCOS group had significantly higher serum uric acid levels (4.36 ± 1.3 mg/dl vs. 3.2 ± 0.73 mg/dl). There was also significantly higher proteinuria level in PCOS patients. Conclusion Even though PCOS patients had higher GFR, serum uric acid and UAE val- ues than control patients, the renal function was within normal limits. Increased GFR in PCOS women positively correlates with elevated serum CRP and uric acid.
