Predictive Factors of Successful Microdissection Testicular Sperm Extraction in Patients with Presumed Sertoli Cell-Only Syndrome
نویسندگان
1 Department of Andrology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedi- cine, ACECR, Tehran, Iran
2 Department of Andrology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedi- cine, ACECR, Tehran, Iran
3 Department of Andrology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedi- cine, ACECR, Tehran, Iran
4 Department of Andrology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedi- cine, ACECR, Tehran, Iran
5 Department of Andrology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedi- cine, ACECR, Tehran, Iran
6 Department of Epidemiology and Reproductive Health at Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
7 Department of Andrology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedi- cine, ACECR, Tehran, Iran
8 Department of Andrology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedi- cine, ACECR, Tehran, Iran
9 Department of Andrology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedi- cine, ACECR, Tehran, Iran;Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Te
doi
10.22074/ijfs.2015.4214چکیده
Background To evaluate predictive factors of successful microdissection-testicular sperm extraction (MD-TESE) in patients with presumed Sertoli cell-only syndrome (SCOS). Materials and Methods In this retrospective analysis, 874 men with non-obstructive azoospermia (NOA), among whom 148 individuals with diagnosis of SCOS in prior biopsy, underwent MD-TESE at Department of Andrology, Royan Institute, Tehran, Iran. The predictive values of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels, testicular volume, as well as male age for retrieving testicular sperm by MD-TESE were analyzed by multiple logistic regression analysis. Results Testicular sperm were successfully retrieved in 23.6% men with presumed SCOS. Using receiver operating characteristic (ROC) curve analysis, it was shown that sperm retrieval rate in the group of men with FSH values >15.25% was 28.9%. This was higher than the group of men with FSH ≤15.25 (11.8%). Conclusion Sperm retrieval rate (SRR) was 23.6% in men with presumed SCOS and FSH level can be a fair predictor for SPR at MD-TESE. MD-TESE appears to be recommendable in such cases (SCOS with high FSH concentration) with reasonable results.
