Trimethyl Phosphite Mediated Simple Synthesis of Coumarins and Azacoumarins Through the Reaction of Phenols or Hydroxypyridines and Dimethyl Acetylenedicarboxylate (DMAD) or Diethyl Acetylenedicarboxylate (DEAD)
نویسندگان
1 Faculty of Chemistry, Islamic Azad University, Tehran North Branch, Tehran, I.R. IRAN
2 Department of Chemistry, Islamic Azad University, Arak Branch, Arak, I.R. IRAN
3 Faculty of Chemistry, Islamic Azad University, Tehran North Branch, Tehran, I.R. IRAN
doi
10.30492/ijcce.2008.6936چکیده
Protonation of the reactive intermediate produced in the reaction between trimethyl phosphite and dimethyl acetylenedicarboxylate or diethyl acetylenedicarboxylate by resorcinol, 5-methylresorcinol, 2,5-dihydroxyacetophenone, 4-chloro-2-methylphenol, 4-chloro-3,5-dimethy-lphenol, 4-hydroxypyridine, 2-hydroxypyridine, 3-hydroxypyridine, or 8-hydroxyquinoline leads to vinylphosphonium salts, which undergo Michael addition with the conjugate base of the OH-acid to produce highly functionalized 2-oxo-2H-chromene or azacoumarins in good yields.
