Comparison of Catalytic Effect of Alkali and Alkaline Earth Metals Hydrogen Sulfate: As the Promoter for an Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones under Solvent-Free Conditions
نویسندگان
1 Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, I.R. IRAN
2 Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, I.R. IRAN
3 Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, I.R. IRAN
4 Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, I.R. IRAN
5 Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, I.R. IRAN
doi
10.30492/ijcce.2005.8118چکیده
Alkali and alkaline earth metals hydrogen sulfate catalyzed the one-pot three component condensation reactions of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under solvent-free conditions leading to 3,4-dihydropyrimidin-2(1H)-ones in high yields at 80 °C. Our results showed that Biginelli reaction not only is pH dependent, but the cation of catalyst plays an important role.
