Influence of Formulation Parameters on the Release of Diclofenace Sodium from Matrices with Manufacturing Formulation Ingredients
نویسندگان
1 Department of Chemical Engineering, Sharif University of Technology, P.O. Box 11365-8639 Tehran, I.R. Iran
2 Department of Chemical Engineering, Sharif University of Technology, P.O. Box 11365-8639 Tehran, I.R. Iran
doi
10.30492/ijcce.2002.9624چکیده
Effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. As a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. The fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose content inside the granule. Results presented here indicate that as PVP content outside the granule or aerosol fraction inside or outside the granule in the matrix increases, the fractional release increases. The fractional release profiles of diclofenac sodium from matrices, when each ingredient is inside or outside, or half inside - half outside the granule, are compared.
