فهرست نشریات علمی دسترسی آزاد ایران

In the current report, we have introduced a novel electrochemical sensor based on a modified glassy carbon electrode (GCE) with molecularly imprinted polymer (MIP) technology, for determination of Dimethyl fumarate (DF). The MIP was assembled on GCE surface by in-situ electro-polymerization of dopamine (DA) as functional monomer and DF as template molecule. Then the polymerized electrode was washed through an appropriate washing solution. The washing process caused the DF molecules to come out of the MIP texture. The end result of this process was the formation of complementary cavities which could rebind with the DF molecule. In order to improve performance of the MIP-based GCE, optimization of key performance parameters such as cycles number, washing and re-uptake times carried out. As well as repeatability, stability, reproducibility and selectivity were evaluated. To characterize the designed sensor, diverse techniques such as Scanning electron microscopy (SEM), cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) were applied. The linear range of the electrochemical sensor was from 5 to 1000 ոM, with a limit of detection (LOD) value of 1.6 ոM. The proposed sensor was successfully used to determination of DF in serum sample.