Perspective on Metal-Ligand Coordination Complexes and Improvement of Current Drugs for Neurodegenerative Diseases (NDDs)
نویسندگان
1 Department of Physical Sciences, Sant Baba Bhag Singh University, Jalandhar, Punjab 144030, India
2 Department of Chemistry, Faculty of Science, J.V. College, CCS University, Baraut, Baghpat, U.P.250 611, India
3 School of Pharmacy, The Glocal University, MirzapurPole, Saharanpur, Uttar Pradesh 247121, India
4 Department of Natural and Applied Sciences, School of Science and Technology, The Glocal University, MirzapurPole, Saharanpur, Uttar Pradesh 247121, India
5 Innovation and Incubation Centre for Entrepreneurship (IICE), Indian Institute of Science Education and Research (IISER), Bhopal, Madhya Pradesh 462 066, India
doi
10.22034/ajca.2023.363929.1334چکیده
Neurodegenerative diseases (NDDs) associated with the steady loss of neural functionality by the action of irreversible damage or death of neurons are one the most serious diseases amongst human beings. The most common NDDs are including Alzheimer’s disease, Prion protein disease, and Parkinson’s disorder. Several coordination complexes are effective in the treatment of NDDs. In the present scenario, computational methods opened a new vista for novel drugs with theoretically improved overall effectiveness. This review highlights the current trends of computational designs of coordination complexes in developing new drug discovery options and their potential to treat different neurodegenerative diseases with up-to-date R&D exploration with future perspectives.
