Development of Modified Electrode-Based Electrochemical Sensing Platform for the Voltammetric Determination of Imatinib
نویسندگان
1 Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
2 Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
3 Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
4 Department of Chemistry, Payame Noor University, Tehran, 19395-4697, Iran
doi
10.48309/chemm.2025.515115.1925چکیده
The present work describes a simple strategy for imatinib determination on the voltammetry basis. This strategy was established through a simple process for modification of screen-printed carbon electrode (SPCE) using nickel-cobalt layered double hydroxide hollow nanostructures (Ni-Co LDH HNSs). The cyclic voltammetry (CV) studies demonstrated a well-defined oxidation peak for imatinib at 570 mV with improved response peak current (13.3 µA) at the surface of Ni-Co LDH HNSs/SPCE compared to unmodified SPCE. The electrochemical quantification of imatinib was conducted using differential pulse voltammetry (DPV). Under the optimum conditions, the modified SPCE exhibited good response for imatinib. The Ni-Co LDH HNSs/SPCE demonstrated a linear concentration range for imatinib (0.008 to 90.0 µM), with a low detection limit (LOD) of 0.005 µM. Finally, it was demonstrated that using a simple tool, the sensing platform could be an alternative strategy for analyzing the pharmaceutical products.
