Synthesis and Molecular Docking Studies of Some Thiohydantoin Derivatives as Potential Anticancer and Antimicrobial Agents
نویسندگان
1 Chemistry Department, Faculty of Science, University of Tripoli, Tripoli, Libya
2 Chemistry Department, Faculty of Science, Sebha University, Sebha, Libya
3 Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sirte University, Sirte, Libya
doi
10.22034/ajca.2021.291823.1266چکیده
2-Thiohydantoin derivatives are most remarkably known because of their extensive applications including, hypolipidemic, anticarcinogenic, antimutagenic, antifungal, and antibacterial. For this reason, three of 5-aryl-2-thiohydantion derivatives (3-5) and the conversion of 2-thiohydantoin to thiol ether (7) by alkylation with methyl bromoacetate are successfully synthesized. To evaluate and understand the interactions and the orientation between the synthesized compounds and binding pocket of cancer and bacterial protein receptor, molecular docking studies using the Auto dock Vina were performed against three proteins including; isocitrate dehydrogenase (IDH1, PDB: 4UMX) and two bacterial proteins (LasR-OC12 HSL complex PDB:3IX3, and β-ketoacyl-acyl carrier protein synthase, PDB:1FJ4). The docking results demonstrated that lower free energy of binding (FEB) was obtained from the synthesized compounds ranging from −5.1 to −9.6 kcal/mol for 3IX3, −4.9 to −7.8 kcal/mol for 1FJ4, and −4.4 to −8.5 kcal/mol for 4UMX.
