فهرست نشریات علمی دسترسی آزاد ایران

Drug resistance by persisters is a global issue that requires urgent attention. Quinolines and quinolones have proven to be important cores in several bioactive organic chemotypes, based on this, the antimicrobial activity of six derivatives of 2,4-diarylquinolines was evaluated using the disc diffusion method at 5-20 µM/mL. The bioactivity evaluation was conducted on four bacteria examples, two of which are ESKAPE bacteria (Staphylococcus aureus, Streptococcus pneumonia, Escherichia coli and Pseudomonas aeruginosa). The results indicated promising minimum inhibitory concentrations (5 and 10 µM/mL in some cases) and encouraging zones of inhibition against the 4 germs while interesting and reasonable structure-activity relationships were established at the end of the study.