Modification of Creatinine to Form New Oxazepane Ring and Study Their Antioxidant Activity
نویسندگان
1 Department of Biochemistry, College of Medicine, University of Misan, Iraq
2 Department of Chemistry, College of Science, University of Baghdad, Jadiriya, Baghdad, Iraq
doi
10.22034/chemm.2021.135020چکیده
In this research new creatinine Schiff bases (1a, 1b, and 1c) were synthesized from the reaction of aromatic aldehydes (4-nitrobenzaldehyde,4-amino benzaldehyde, and cinnamaldehyde) with creatinine, in few drops of glacial CH3COOH as a catalyst in C2H5OH. Then, seven-member rings were prepared (oxazepine) (2a-4c) on creatinine form treatment of imines with (phthalic, maleic, and succinic anhydrides. Synthesized compounds were identified by IR, melting point, and 1H-NMR of some of them. Some of the prepared compounds were studded with antioxidant activity.
