Feasibility and Toxicity of Intra-Articular 188Re-tin Colloid Injection in Patients with Rheumatoid Arthritis with Three-Phase Positive Bone Scan and Refractory Knee Pain, a pilot study
نویسندگان
1 Rheumatic Diseases Research Center (RDRC), Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Rheumatic Diseases Research Center (RDRC), Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5 Nuclear Medicine Department, Razavi Hospital, Imam Reza International University, Mashhad, Iran
6 Rheumatic Diseases Research Center (RDRC), Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
7 Rheumatic Diseases Research Center (RDRC), Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
8 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
doi
10.22631/rr.2020.69997.1098چکیده
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes chronic synovial inflammation. Reactor-producedβ-particle emitting radionuclides is a new therapeutic strategy in the management of RA. This study was conducted in 2019and analyzed the toxicity and feasibility of 188Re-tin colloid injection, Three-Phase Positive Bone Scan, and Refractory KneePain. Ten patients with RA were administered radiosynovectomy with 188Re-tin colloid. The main complications after theintervention were assessed and compared with patients’ pre-intervention condition. Patients showed alleviation of pain,tenderness, and morning stiffness after the administration of radiosynovectomy. Only one RA patient received a corticosteroidinjection; the other 6 patients did not need a corticosteroid injection after radiosynovectomy. Intra-articular 188Re-tin colloidinjection seems to be an effective treatment modality for refractory knee joint pain in rheumatoid arthritis patients. Thus, it issuggested as a safe and effective strategy to apply.
