Layered Double Hydroxides (LDHs): An Efficient Catalyst System for the Synthesis of Chiral Aminonitriles

نویسندگان
Tondfekr, Reza ID 1
Karbasi, Farnaz ID 2
Tahoori, Fatemeh ID 3
Moradinejad, Mona ID 4

1 Department of Chemistry, Iran University of Science and Technology, Tehran, Iran

2 Department of Chemistry, Tehran East branch, Islamic Azad University, Tehran, Iran

3 Razi Vaccine and Serum Research Institute, Agricultural Research and Extension Organization (AREEO), Karaj, Iran

4 Department of Chemistry, Tehran East branch, Islamic Azad University, Tehran, Iran

doi
10.22036/org.chem..2017.79473.1087
چکیده

Strecker reaction is one of the simplest multicomponent reactions. It used for synthesis of chiral α-amino nitriles. This reaction was carried out in the presence of catalytic amount of layered double hydroxides (LDHs). In this study, simple and practical method for the synthesis of this class of catalysts is provided. The results shown that LDH is the good heterogen catalyst for synthesis of chiral α-amino nitriles.

کلیدواژه‌ها
Layered double hydroxide (LDHs), Strecker reaction, α-Amino acids, Diastereoselectivity