فهرست نشریات علمی دسترسی آزاد ایران

Fruit flies known scientifically as Drosophila melanogaster provide essential research benefits for understanding human neurological disorders through their human-like genetics and highly developed genetic research capabilities. Scientists use Drosophila as an efficient disease mechanism study because approximately 75% of human disease-related genes possess counterparts in Drosophila. The GAL4/UAS system enables researchers to control which tissues and specific time periods activate gene expression and forward and reverse genetic approaches help identify genes that contribute to neurodegeneration along with their functional assessment. The modifier screen methodology allows scientists to find genes which either increase or reduce disease manifestation. These research tools alongside the well-understanding of Drosophila nervous system and short life span make this organism optimal for simulating diseases including Alzheimer's along with Parkinson's and Huntington's disease and amyotrophic lateral sclerosis (ALS). Through Drosophila research models scientists study how proteins aggregate as well as synaptic breakdown and oxidative damage which are common abnormalities in neurodegenerative disorders. Behavioural tests combined with tissue analysis techniques together with automated drug screening help scientists advance disease research and therapeutic discovery. The structural dissimilarities between flying insects and humans fail to diminish Drosophila's usefulness for studying neurological processes in human disease investigations. The review presented insights about genetic research and laboratory applications of D. melanogaster to study neurological diseases and develop intervention strategies.