فهرست نشریات علمی دسترسی آزاد ایران

The objective of this study was to extract and assess the pharmacological potential of the fixed oil derived from P. foetida L. leaves; in light with the paucity of research on the chemical composition of P. foetida leaves fixed oil. Fresh leaves of P. foetida L. were collected from uncultivated land at Sheda Science and Technology Complex (SHESTCO), Abuja. The Clevenger apparatus was used to extract the fixed oil. Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier Transform Infrared (FTIR) analysis was performed to chemically characterize the fixed oil. Antibacterial activity was also assessed against Staphylococcus aureus and Escherichia coli using the agar disc diffusion method, while antioxidant activity was evaluated using the DPPH radical scavenging assay. FTIR analysis revealed the presence of hydroxyl, carbonyl, alkane, and amide groups, suggesting potential bioactivity. The GC-MS Agilent Intuvo 9000Gc model revealed 30 identified bioactive compounds with diverse pharmaceutical potentials. The antibacterial assays showed significant activity with maximum inhibition zones of (18.05) mm on S. aureus and (13.01 mm) on E. coli. The antioxidant analysis demonstrated concentration-dependent radical scavenging activity, with a maximum inhibition of (64.5% at 0.5 mg/mL). These findings support the traditional uses of P. foetida L. and highlight its potential for developing natural antibacterial and antioxidant agents. The fixed oil of P. foetida L. shows significant antibacterial and antioxidant properties, making it a candidate for nutraceutical and therapeutic applications. Further studies are recommended to isolate specific compounds and explore their mechanisms of action.