An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)
نویسندگان
1 Department of Chemistry, Alzahra University, P.O. Box 1993891176 Tehran, I.R. IRAN
2 School of Chemistry, University of Tehran, P.O. Box 14155-6455 Tehran, I.R. IRAN
3 Department of Chemistry, Alzahra University, P.O. Box 1993891176 Tehran, I.R. IRAN
4 School of Chemistry, University of Tehran, P.O. Box 14155-6455 Tehran, I.R. IRAN
doi
10.30492/ijcce.2016.18802چکیده
One-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) and resulted in the formation of spirooxindole dipyrimidines. Spirooxindole unit is found in many natural products and biologically active molecules and 1,4-dihydropyridines are an important class of compounds with interesting biological activities such as vasolidator, antitumor, antidiabetic, bronchodilator and anti-atherosclerotic activities. Excellent yields and short reaction timesare related to the highefficiency of SBA-Pr-SO3H that the reactions take place easily in its nano-pores. Mild reaction conditions and easy work-up procedures are other advantages of this green method.
