فهرست نشریات علمی دسترسی آزاد ایران

Lactobacillus species, which are beneficial and non-pathogenic Gram-positive rods, are commonly found in the vaginal microbiota of healthy premenopausal women. These bacteria play a crucial role in maintaining vaginal health by producing substances that inhibit the growth of harmful microorganisms. The purpose of this study was to assess the prevalence and incidence of Group B Streptococcus (GBS), a significant pathogen associated with neonatal infections and other health risks, among pregnant women in Wukari, a town in Taraba State, Nigeria. In addition, the study aimed to explore the ability of bacteriocins—antimicrobial peptides produced by Lactobacillus species—to inhibit a broad spectrum of both Gram-positive and Gram-negative bacteria. To achieve this, a total of 50 samples were collected from pregnant women in Wukari. Out of these, 11 samples (22%) were found to be colonized by Group B Streptococcus, while 14 samples (28%) showed a positive response to Lactobacillus species, indicating the presence of beneficial bacteria capable of providing a protective effect. The study further examined the inhibitory effects of crude and partially purified bacteriocin-like inhibitory substances produced by Lactobacillus isolates on Group B Streptococcus. The results demonstrated that these inhibitory activities were most effective at 30 °C and an acidic pH of 5.5, suggesting optimal conditions for bacteriocin production or activity.