فهرست نشریات علمی دسترسی آزاد ایران

Background: Burn injuries compromise skin integrity, increasing infection risk, and complicating healing. This study investigates the effectiveness of a probiotic spray in improving burn wound healing outcomes. Specifically, it examines wound closure rates, reduction in infection frequency, and inflammation control in patients with second-degree burns.Methods: In this controlled clinical trial conducted at Velayat Burn Injuries Hospital in Rasht, Iran, 28 patients with second-degree burns were divided into two groups: one group received standard treatment, while the other group was treated with a probiotic spray containing 10⁹ CFU/mL, which was applied twice daily for 28 days. Variables assessed included wound healing rate, infection occurrence, inflammatory response, and any adverse reactions. Wound conditions were monitored on days 1, 7, 14, 21, and 28, with effectiveness evaluated through both clinical and microbiological assessments.Results: The probiotic spray group demonstrated superior outcomes, including a 90% reduction in wound size by 28 days and a marked decrease in infection incidence and inflammation compared to the control group. Analysis revealed that probiotic treatment facilitated re-epithelialization and modulated the wound microbiome by promoting beneficial bacterial growth and supporting immune response regulation, contributing to accelerated healing.Conclusion: Probiotic spray treatment demonstrated potential as an effective therapeutic option in burn wound care, providing enhanced healing, reduced infection, and inflammation management. The findings underscore the potential of integrating probiotic therapy into standard burn care to reduce antibiotic dependence and improve patient outcomes, particularly in resource-limited settings.