Epigenomic profiling in Cancer: Techniques and Therapeutic Implications
نویسندگان
1 Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Oyo State, Nigeria
2 Department of Bioinformatics, School of Health and life Sciences, Teesside University, UK
3 Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Nigeria
4 Department of Community Medicine, School of Medical Sciences, University of Cape Coast, Ghana
5 Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Benin, Nigeria
6 Department of Nutritional Sciences, Faculty of Pharmacy and Nutritional Sciences, University of Calabria, Italy
7 Department of Bioinformatics, School of Health and life Sciences, Teesside University, UK
8 School of Basic Medical Sciences, Federal University of Technology, Akure, Ondo State, Nigeria
9 Department of Anatomy, Faculty of Basic Medical Science, University of Ilorin, Kwara State, Nigeria
10 Department of Human Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria
11 Department of Medicine and Surgery, Faculty of Clinical Sciences, University of Ibadan, Oyo State, Nigeria
12 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Nigeria
13 Department of Biology, Faculty of College of Science and Technology, North Carolina Agriculture and Technical University, UK
doi
10.48309/ijabbr.2025.2035869.1534چکیده
Understanding the control of gene expression and its consequences for cancer biology is greatly aided by the field of epigenomics, which is the study of epigenetic changes throughout the genome. Epigenetic modifications, including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA regulation, affect gene activity without altering the DNA sequence, in contrast to genetic mutations. These alterations have a critical role in controlling gene expression, which affects cellular functions such as growth, differentiation, and death. Epigenetic modifications play a major role in cancer by causing dysregulated gene expression, which silences tumor suppressor genes, activates oncogenes, and encourages genomic instability. For instance, hypermethylation of CpG islands at the promoters of tumor suppressor genes, such as p16INK4a and BRCA1, results in the transcriptional repression of these genes. In contrast, global hypomethylation activates oncogenes and causes chromosomal instability. Gene expression and the development of cancer are also highly impacted by histone alterations and chromatin remodeling. The methods for characterizing epigenetic changes, such as DNA methylation, histone modifications, chromatin accessibility, and non-coding RNA interactions, are explained in this article. It emphasizes how important these methods are for identifying the epigenetic changes that contribute to the development and progression of cancer. By addressing therapeutic implications and new treatments like DNA methylation and histone deacetylase inhibitors, this review closes the gap between basic epigenomic changes and their possible application in clinical practice. This study intends to improve cancer detection, prognosis, and treatment by providing a thorough grasp of epigenomic profiling, opening the door for more individualized and successful therapeutic approaches.
