Recent Discoveries and Clinical Applications of Deoxyribonucleic Acid (DNA) Methylation Inhibitors in the Diagnosis, Classification, and Treatment of Meningiomas
نویسندگان
1 University for Development Studies, Ghana
2 Department of Pharmacology, Toxicology and Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Nigeria
3 University of Illinois at Spingfield, Springfield, Illinois, USA
4 Clinical Rehabilitation Division, Nyaho Medical Centre, Accra, Ghana
5 University of Wolverhampton, USA
6 Ladoke Akintola University of Technology, Nigeria
7 University for Development Studies, Ghana
8 University for Development Studies, Ghana
9 University of Benin Teaching hospital, Edo state, Nigeria
10 Enugu State University of Science and Technology, Nigeria
11 Department of Medical Laboratory Science, Ladoke Akintola University of Technology Ogbomoso, Nigeria
12 Nigerian Institute of Medical Research, Lagos, Nigeria
13 Department of Biochemistry, Bayero University Kano, Nigeria
14 Department of Ecology and Evolutionary Biology, Tulane University, New Orleans Louisiana, Nigeria
doi
10.48309/ijabbr.2025.2037375.1531چکیده
Recent advancements in molecular biology and genomics have revolutionized our understanding of meningiomas, leading to novel diagnostic and treatment strategies. Meningiomas are common central nervous system tumors and their management has traditionally relied on histopathological classification. However, the integration of DNA methylation analysis has provided new understanding into the molecular activities of these tumors, providing potential biomarkers for personalized medicine. This review involved a comprehensive search of electronic databases (e.g., PubMed, Web of Science, and Scopus) was conducted to identify relevant studies based on keywords related to DNA methylation inhibitors, meningioma, diagnosis, classification, and treatment. This study was aimed at assessing the recent discoveries regarding DNA methylation inhibitors and their potential clinical applications in diagnosing, classifying, and treating meningiomas. DNA methylation inhibitors are applied in modulating gene expression patterns in meningiomas and Nucleoside analogs demonstrated potential in inhibiting meningioma cell growth by inducing apoptosis through DNA hypomethylation. These inhibitors, when used in combination with conventional treatments, could enhance treatment efficacy, overcome drug resistance, and reduce tumor recurrence, as they can be specifically used to target specific molecular subtypes of meningiomas.
