Comparison of the effect of ferrous sulfate and ferrous gluconate on prophylaxis of iron deficiency in toddlers 6-24 months old: A randomized clinical trial
نویسندگان
1 Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
2 Department of Epidemiology, Arak University of Medical Sciences, Arak, Iran
3 Department of Social Medicine, Arak University of Medical Sciences, Arak, Iran
4 Department of Health Information Technology, Faculty of Paramedical, Ilam University of Medical Sciences, Ilam, Iran
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6 Department of Basic and Laboratory Sciences, Khomein University of Medical Sciences, Khomein, Iran
7 Clinical Research Development Center of Aliasghar Hospital, Iran University of Medical Sciences, Tehran, Iran
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doi
چکیده
BACKGROUND: Iron deficiency anemia (IDA) is one of the most common anemias, especially inchildren 4–23 months. Therefore, prophylaxis is necessary to improve iron status as well as reduceIDA in Toddlers. The aim of this study was to compare the efficacy of daily supplementation withferrous gluconate (FG) and ferrous sulfate (FS) on iron status in toddlers.MATERIALS AND METHODS: A total of 120 healthy toddlers were divided randomly into 2 groups atthe Amir‑Kabir Hospital, Arak, Iran and received FS and FG from March 2020 to December 2020. Ironstatus was evaluated at baseline and after 6 months of supplementation. The statistical significanceof the differences in iron status between FS and FG groups was calculated using Student’s t‑testand the Pearson’ s Chi‑square test for qualitative variables. SPSS software (version 16, Chicago,IL, USA) was used for statistical analysis.RESULTS: Comparison of iron status of FS and FG groups toddlers at baseline and after 6 monthsof supplementation showed that there was a significant difference in hemoglobin (Hb) (10.46 vs.12.45, P = 0.001) and ferritin level (28.08 vs. 59.63, P = 0.001).CONCLUSIONS: Although prophylaxis with FG led to a higher Hb and ferritin levels, our studyrecommended that both FG and FS supplements were effective for prophylactic use in theprevention of IDA. However, FG was more effective than FS because FG group that received FGsupplementation indicated a higher Hb and ferritin levels in comparison to the FS group that receivedFS supplementation.
