Antibacterial Activity of Some New Azole Compounds: Antibacteria activity of azole compounds
نویسندگان
1 Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3 Pharmaceutical Sciences Resaerch Center,and cDepartment of Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
4 Pharmaceutical Sciences Resaerch Center,and cDepartment of Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
5 Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
doi
10.22037/ijps.v8.40928چکیده
We have previously synthesized new N-alkylated azoles (1b-7b) as antifungal agents. Here, we evaluated the antibacterial activities of these compounds against two gram positive and two gram negative bacteria by broth microdilution method. The aminothiazole derivative (7b) showed an excellent antibacterial activity. Other compounds exhibited moderate to good antibacterial activity. All compounds are moreactive against gram positive than against gram negative bacteria.
