فهرست نشریات علمی دسترسی آزاد ایران

Background: Oropharyngeal carcinoma (OPC) remains a significant health concern in India, particularly driven by tobacco use. While human papillomavirus (HPV)-associated OPC is increasingly common in Western countries, the Indian clinical landscape presents a distinct pattern. Aim: Evaluation of the clinical presentation, risk factors, treatment modalities, and short-term outcomes of 50 OPC patients treated at a tertiary care center in Delhi over two years. Methods: This is a cohort study on patients diagnosed with OPC between January 2023 and December 2024. Data included demographics, risk exposures, staging, treatment, and follow-up. Results: Of the 50 patients, 76% were male, with a median age of 57 years. Tobacco use was present in 88% of cases. Only 12% of tested cases were HPV-positive. The majority (74%) presented with advanced-stage disease. Most were treated with concurrent chemoradiotherapy (62%), followed by surgery with adjuvant therapy (20%). At a median follow-up of 18 months, the overall response rate was 72%, with 46% achieving complete response. Conclusion: OPC in Delhi is predominantly tobacco-related and often presents at an advanced stage. Chemoradiotherapy remains the cornerstone of treatment, though early detection and prevention strategies are essential for improving outcomes.