Cardiac Sarcoidosis: A Contemporary Concept of Forgotten Granulomatosis
نویسندگان
1 Department of Rheumatology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
2 Internal Deceases Propaedeutic Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
3 Histology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
4 Histology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
5 Internal Deceases Propaedeutic Department, Kuban State Medical University, Krasnodar, Russia
6 Heart Failure Research Centre, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
7 Isfahan Cardiovascular Research Center , Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
8 Department of Anatomical Pathology and Clinical Morphology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
9 Department of Cardiology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
10 Department of Pathophysiology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
11 Rheumatology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
12 Biology Department with a course of Medical Genetics, Kuban State Medical University, Krasnodar, Russia
13 Experimental and Clinical Pathology Department, Al. Natishvili Institute of Morphology, Iv. Javakhishvili Tbilisi State University, Tbilisi, Georgia
doi
10.48305/arya.2023.41534.2888چکیده
Sarcoidosis is a complex multisystem inflammatory granulomatous disease that can affect any organ, with a wide range of clinical presentations. A significant number of patients with systemic sarcoidosis may also have cardiac involvement. Clinical manifestations of cardiac sarcoidosis can include various rhythm and conduction disturbances, as well as heart failure.The structure of sarcoid granulomas is similar to that of tuberculous granulomas, but in contrast, they lack caseous necrosis. Tissue changes in sarcoidosis tissues depend on the stage of development of the disease, progressing from pathological process: macrophage-lymphocytic infiltration to epithelioid cell granuloma formation, and fibrosis. Granulomas can be found in any part of the myocardium, with the most common locations being the free wall of the left ventricle, the basal part of the interventricular septum, and the interatrial septum. Vasculopathy of the pulmonary circulation and coronary arteries is often observed.Advancements in diagnostic imaging techniques, such as computer tomography and magnetic resonance imaging, have facilitated the verification of cardiac sarcoidosis. This article presents an analysis of updated information on cardiac sarcoidosis by a multidisciplinary working group.
