Comparison of Pulmonary Artery Pressure before and after Kidney Transplantation in Kidney Transplant Patients with Pulmonary Hypertension
نویسندگان
1 Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Community Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran
doi
10.48305/arya.2022.11802.2458چکیده
BACKGROUND: Pulmonary hypertension (PH) is a common finding i n c hronic k idney d isease (CKD)and is associated with increased mortality and morbidity. The effect of kidney transplantation on PH is notyet well evaluated. This study aimed to compare pulmonary artery pressure (PAP) before and after kidneytransplantation in CKD patients.METHOD: This longitudinal study was conducted on 33 CKD patients who were candidates for kidneytransplantation in a tertiary hospital in Mashhad, Iran. Pulmonary artery pressure and ejection fraction (EF)were assessed using trans-thoracic echocardiography (TTE). Demographic and clinical findings, includingage, gender, and body mass index (BMI), as well as laboratory assessments, including hemoglobin, serumcalcium and phosphorus level, and parathyroid hormone, were recorded before transplantation. TTEassessment was repeated one year after transplantation.RESULTS: Mean age of the study patients (17 males and 16 females) was 30.42 ± 9.71 years. The majorityof patients (85%) received hemodialysis before transplantation. Compared to before transplantation,PAP significantly decreased (from 33.67 ± 6.78 to 26.06 ± 5.78 mmHg, P<0.001) and EF increased (from52.85 ± 7.12 to 57.03 ± 4.08, P=0.003) one year after transplantation. A significant positive correlation wasfound between PAP difference and EF before transplantation.CONCLUSIONS: The findings o f t his s tudy s howed t hat k idney t ransplantation w as c orrelated withimproved PAP and EF one year after transplantation and EF before kidney transplantation was correlatedwith PAP changes.
