فهرست نشریات علمی دسترسی آزاد ایران

BACKGROUND: Hypertension (HTN) is the second leading risk factor for death and disability.One fourth of healthcare in Eastern Europe and Central Asia is being spent on blood pressure(BP)-related diseases. An important situation in patients with high BP is hypertensive crisis(BP > 180/120 mmHg), which is divided to hypertensive emergency and urgency. Therefore,here, we decided to compare the effect of captopril and clonidine in patients with hypertensiveurgencies, and their side effects.METHODS: This was a parallel-group randomized clinical trial. Patients, who referred toemergency ward with any symptoms of hypertensive crisis, underwent a careful history takingand clinical examination. Individuals with systolic BP (SBP) ≥ 180 mmHg or diastolic BP (DBP)≥ 110 mmHg with no evidence of end organ damage were randomly assigned into twointerventions, clonidine and captopril. 25% decrease in BP was considered as ideal relief.RESULTS: Regarding the duration of response to treatment drugs, patients who receivedclonidine relieved significantly faster than those who received captopril (P = 0.016). Moreover,the frequencies of side effects such as headache, dizziness/vertigo, dry mouth, and drowsiness inthe clonidine group were significantly lower than captopril group (P < 0.05).CONCLUSION: Patients in clonidine group relieved sooner and experienced fewer side effects.Therefore, this study suggests clonidine as a more effective therapeutic for hypertensive urgencycompared with captopril.