فهرست نشریات علمی دسترسی آزاد ایران

Background and objectives:  Probiotics have recently emerged as adjunctive agents to conventional periodontal treatment, aiming to improve clinical outcomes. This study systematically reviews published literature evaluating the potential clinical benefits of probiotics in treating chronic periodontitis. Materials and methods:  A search of the MEDLINE database (via PubMed) was conducted up to November 2020. Randomized clinical trials (RCTs) in English comparing probiotics to a placebo for treating chronic periodontitis were selected. Clinical outcome variables included probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), and bleeding on probing (BOP). Results:  Eight studies met the inclusion criteria. All were double-blind, parallel-arm, placebo-controlled RCTs. Six studies reported a statistically significant reduction in PPD, while four studies showed a beneficial reduction in BOP and PI compared to the control group. Conclusion:   Probiotic consumption appears to moderately improve the treatment of chronic periodontitis. However, heterogeneity among studies may limit the strength of this conclusion.