Incidence and Risk Factors of Neural Tube Defects in Kashan, Central Iran
نویسندگان
1 1. Department of Pediatrics, Kashan University of Medical Sciences, Kashan, Iran
2 4. Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran
3 1. Department of Pediatrics, Kashan University of Medical Sciences, Kashan, Iran
4 2. Department of Community Medicine, Kashan University of Medical Sciences, Kashan, Iran
5 3. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
6 3. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
doi
10.22037/ijcn.v9i3.6995چکیده
How to Cite This Article: Talebian A, Soltani B, Sehat M, Zahedi A, Noorian A, Talebian M. Incidence and Risk Factors of Neural Tube Defects in Kashan, Central Iran. Iran J Child Neurol. Summer 2015;9(3):50-56.AbstractObjectiveNeural tube defects (NTDs) are the most common congenital defects of centralnervous system due to neural tube closure deficit during the third and fourthweeks of gestational age. Our study was performed to detect the incidence andrisk factors of NTDs in Kashan, center of Iran.Material & MethodsThis case-control study was done on all pregnancies with NTD affectedneonates (n=91) and 209 pregnancies with normal neonates from February2007 to December 2012 in three hospitals in Kashan, center of Iran. Annual andthe mean incidence of NTDs were calculated. Risk factors including neonatalgender, maternal age, gravidity, maternal abortion history, maternal gestationaldiabetes (GDM), folic acid use, familial marriage, maternal body mass index(BMI), birth season and family history of NTDs were evaluated by interviewwith mothers. Univariate and multivariate logistic regression were used toanalyze the risk factors.ResultsThe mean incidence of NTDs was 2.33 per 1000 births. The multivariate analysisindicated that maternal history of abortion (OR: 4.9, CI: 1.9-12.8), and maternal obesity (OR: 5.4, CI: 1.3-21.8) were significantly associated with NTDs.ConclusionMaternal history of abortion and BMI were the major risk factors of NTDs.
