Recent Progresses in Brain Gene Therapy
نویسندگان
1 Assistant Professor of Neurosurgery. Member of Functional Neurosurgery Research Center of Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences.
2 Associate Professor of Neurosurgery , Functional Neurosurgery Research Center , Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences
3 Department of Neurology, Semnan University of Medical Sciences, Semnan, Iran
4 Department of Neurology, Semnan University of Medical Sciences, Semnan, Iran
5 Functional Neurosurgery Research Center , Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences.
6 Department of Neurology, Amol University of Medical Sciences, Amol, Iran
doi
10.22037/icnj.v3i4.14981چکیده
Gene therapy consists of the introduction of genetic material into cells for a therapeutic purpose. The understanding of the basics of the molecular and cellular mechanisms in disease treatments has resulted in the development of high-tech gene transfer materials with improved therapeutic efficacy. Based on the results of more than 2000 clinical trials to date, gene therapy is going to be included in standard treatment approaches in some specific diseases. Also, gene therapy has been highly improved in central and peripheral nervous system diseases. This review tried to focus on techniques and approaches in brain tumors and nervous system’s gene therapy strategies and will discuss about associated problems and potential future in management of inherited or acquired neurological disorders.
