Protective Effects of Lycopene and Tomato Extract Against Doxorubicin-Induced Cardiotoxicity: Cardioprotective effect of lycopene
نویسندگان
1 Department of Pharmacodynamy and Toxicology, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Pharmacognosy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Pharmacodynamy and Toxicology, Mashhad University of Medical Sciences, Mashhad, Iran.
doi
10.22037/ijps.v1.39448چکیده
The protective effect of tomato extract and lycopene on acute doxorubicin-induced myocardial toxicity was evaluated in mice. Doxorubicin toxicity, induced by asingle intraperitoneal injection (15 mg/kg), was revealed by elevated serum CPKMB and histopathological observations. Tomato extract (1.2 and 2.4 g/kg, i.p.) andlycopene (1.7 and 3.5 mg/kg, i.p.), prevented the rise in serum CPKMB and ameliorated cardiac cell injury. These results suggest that tomato extract andlycopene inhibit doxorubicin-induced cardiotoxicity and might serve as a combination chemotherapeutic agent with doxorubicin to limit its cardiotoxic effects.
