Effects of 2-Alkylamino-Substituted Dihydropyridines on Rabbit Jejunum: Effect of substituted dihydropyridines on jejunum
نویسندگان
1 Department of Medicinal Chemistry, Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O.Box 91775-1365 , Mashhad, Iran.
2 Biotechnology and Pharmaceutical Sciences Research Center, Postal Code 9196773117, Bu-Ali Square, Mashhad, Iran.
3 Department of Pharmacology, Jinnah Medical and Dental College, Karachi, Pakistan.
doi
10.22037/ijps.v1.39438چکیده
In order to investigate the effects of dimethylamino substituent at postion 2 of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-dimethylamino)ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyrdinedicarboxylates (6a-f) were synthesized. The synthesis was started from dialkyl 1,4-dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously. Rabbit jejunum was used to determine the relaxant or antagonistic activity of the synthesized compounds.Some of the compounds (6c-e) inhibited the spontaneous contractile activity of jejunum, dose-dependently and completely, while high-K+ contracted tissues wererelaxed partially.
