Comparing Para-clinical and Laboratory Methods of Covid-19 Diagnosis in Iran
نویسندگان
1 Convergent Technology Research Center, Tehran University, Tehran, Iran
2 Department of Immunology, Faculty of Medical Science, Isfahan University of medical sciences, Isfahan, Iran
3 Department of Medical Laboratory Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Immunology, Faculty of Medical Science, Shahed University, Tehran, Iran
5 Department of Immunology, Faculty of Medical Science, Isfahan University of medical sciences, Isfahan, Iran
6 Department of Immunology, Faculty of Medical Science, Isfahan University of medical sciences, Isfahan, Iran
doi
10.22037/aab.v13i.37244چکیده
Introduction: Coronavirus Disease (COVID-19) caused by Severe Acute RespiratorySyndrome Coronavirus (SARS-CoV-2) was first discovered in China in late 2019 and spreadrapidly worldwide. This study aimed to correlate positive real time Reverse TranscriptasePolymerase Reaction (RT-PCR) results after one month of follow-up with laboratory findingsof the same patients at hospital admission to predict clinical outcome and diagnosis.Materials and Methods: We conducted a retrospective study on the laboratory findings of299 adult patients suspected of COVID-19. Patients were admitted to hospital from March21 to May 25, 2021 with final follow-up of one month for each patient. After one month offollow-up, 233 patients recovered; however, in 64 patients the symptoms worsened. For thesepatients RT-PCR was performed and some patients needed chest Computed Tomography(CT) imaging and were hospitalized. We extracted laboratory findings of these 64 patients andcorrelated the results of their RT-PCR with their laboratory findings.Results: Based on our findings, severe cases are middle-aged adults (P=0.001) withlymphopenia (P<0.001), decreased levels of white blood cells (WBCs) (P<0.001), and platelets(P=0.007) count along with elevated COVID-19 IgG antibody (P=0.002) and ErythrocyteSedimentation Rate (ESR) (P<0.001).Conclusion: RT-PCR is not necessary at admission; instead, some routine hematologyexaminations and serological tests can predict the prognosis of COVID- 19 disease.
