فهرست نشریات علمی دسترسی آزاد ایران

Human dental pulp is a unique connective tissue able to respond to the invasion of pathogens and their by-products in the root canal system via inflammatory reactions in order to remove etiological factors and encourage healing; resulting in “Pulpitis”, which is namely defined by the accumulation of inflammatory mediators, specifically pro-inflammatory cytokines and chemokines. However, if the inflammation progresses and pathogens are not appropriately reduced or eliminated, pulp necrosis will ultimately occur; causing the need for radical pulpectomy and consequently, loss of tooth vitality. Vital pulp therapy (VPT), as a concrete example of regenerative endodontics, is based upon minimally invasive concept; in which the conservation of compromised or inflamed dental pulpal tissue is of critical importance for dentine-pulp regeneration. Pro-inflammatory cytokines, as host modulators, play a significant role in the amendment of intensity and duration of immune response to pathogenic factors. Since the modulation of inflammation is crucial in reaching successful outcomes in VPT, anti-cytokine therapy may assist in achieving the aforementioned results. In addition, when the amount of pro-inflammatory cytokines increases, the pulpal inflammation seems to escalate and negatively affect the tissue healing. Therefore, if cytokines are modulated, the inflammatory process can be favourably controlled, and the healing of dental pulp tissue may be promoted.