Early Diagnosis of Drug-Induced Thrombocytopenia in a Patient with Major Depressive Disorder: A Case Report Highlighting Diagnostic Challenges and Multidisciplinary Management: Early Diagnosis of Drug-Induced Thrombocytopenia in a Patient with Major Depressive Disorder: A Case Report Highlighting Diagnostic Challenges and Multidisciplinary Management
نویسندگان
1 a) Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. b) Kashmar School of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
3 Kashmar School of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Department of Internal Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
5 a) Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; b) Department of Hematology and Blood Banking, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6 . a) Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. b) Kashmar School of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
doi
10.22037/amls.v11.44682چکیده
Background and Aim: Drug-induced thrombocytopenia (DIT) is a rare but potentially life-threatening condition triggered by certain medications. This report aims to emphasize the importance of early diagnosis and appropriate management of DIT in patients with Major Depressive Disorder (MDD) treated with a polypharmacy regimen. Case Presentation: A case study of a 39-year-old woman with MDD who developed bleeding following treatment with “aripiprazole”, “olanzapine”, “lorazepam”, and “sodium valproate” is presented. Conclusion: The patient’s condition improved significantly after medication changes and close collaboration between psychiatrists and hematologists. This highlights the need for proper care and correct prescription of medicines for patients with MDD. Laboratory Highlights & Technical Implications: This case report demonstrates the need for: · Enhanced CBC review protocols for patients receiving psychiatric care/treatment who are on polypharmacy; · Reflex testing algorithms for thrombocytopenia (low platelet count) workups; · Standardized communication channels between lab and mental health teams. Keywords: Drug-Induced Thrombocytopenia; Platelet; Major Depressive Disorder (MDD); CBC Monitoring; Antidepressants; Psychotropic Medications/Drugs; Lab-Clinic Collaboration. *Corresponding author: Mohammad Khani-Eshratabadi; Email Addresses: khaniem@mums.ac.ir, lskhani@yahoo.com; ORCID iD: https://orcid.org/0000-0002-7592-0237 Please cite this article as: Khezri S, Younesi Moghaddam N, Mazarloo M, Bagheri N, Saberi Amarghan S, Khani-Eshratabadi M. Early Diagnosis of Drug-Induced Thrombocytopenia in a Patient with Major Depressive Disorder: A Case Report Highlighting Diagnostic Challenges and Multidisciplinary Management. Arch Med Lab Sci. 2025;11:1-3 (e2). https://doi.org/10.22037/amls.v11.44682
