Comparing the Effectiveness and Safety of Intravenous Levetiracetam and Phenobarbital as First-Line Therapies for Neonatal Seizures: A Randomized Clinical Trial: Levetiracetam and Phenobarbital as first-line therapies for neonatal seizures
نویسندگان
1 Associate Professor of Neonatology, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
3 Associate professor of Pediatric Neurology, Deviation of Pediatric Neurology, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
4 Student Resesarch committe, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Department of Pediatrics, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
doi
10.22037/ijcn.v19i2.45234چکیده
ObjectivesThis randomized clinical trial aims to evaluate and compare phenobarbital and levetiracetam effectiveness and safety in controlling neonatal seizures as first-line therapeutic options.Materials & MethodsNeonates with seizure manifestations presenting to the Bahrami Hospital from March 2020 to March 2022 were enrolled in this study. Patients’ data were recorded, including demographic findings, anthropometric measurements, birth characteristics, and laboratory findings. Patients were randomly divided into the phenobarbital and levetiracetam treatment groups. Outcomes defined as adverse effects, response to medication, time to start enteral feeding, and length of hospital stay were compared between the two treatment groups.ResultsThe current study comprises 44 neonates divided into phenobarbital and levetiracetam groups. Seizure control among the two groups was not significantly different, with levetiracetam and phenobarbital groups showing seizure control of 68.2% and 59.1%, respectively. Moreover, no significant difference was observed regarding the duration of hospitalization and time to initiate feeding. No adverse effect was reported in either group.ConclusionThis study showed no significant difference between levetiracetam and phenobarbital for neonatal seizure control.
