Acute Necrotizing Encephalopathy in Children: Insights and Outcomes from Iran: A Single Centre Original Research in Acute Necrotizing Encephalopathy of Childhood
نویسندگان
1 Department of Radiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
7 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
8 Clinical Research Development Unit, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
9 School of Medicine, Faculty of Medical Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran
10 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
11 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
12 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
13 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
doi
10.22037/ijcn.v18i4.45458چکیده
ObjectivesAcute necrotizing encephalopathy of childhood (ANEC) is a rare, potentially life-threatening condition. This study aimed to identify clinical profiles and outcomes of ANEC while assessing the accuracy of severity scoring in the Iranian population.Materials & MethodsThe present study collected demographic, clinical, laboratory, and radiological data from children diagnosed with ANEC. Severity was measured using the ANE-Severity Score (ANE-SS), while outcomes were assessed with the Glasgow Outcome Score (GOS). This research analyzed the relationship between these scores and various parameters for statistical significance.ResultsSeven patients were included over three years, with an average age of 4.4±2.7 years (5 males). ANE-SS varied from moderate to high, with most patients experiencing moderate to severe disabilities, as indicated by the GOS. Significant correlations were found with initial serum magnesium levels, pupil light reactivity, and initial GCS score (P-value < 0.05).ConclusionControlling initial magnesium levels may improve ANEC outcomes. Additionally, intact pupil light reactivity at admission was associated with a better prognosis.
