فهرست نشریات علمی دسترسی آزاد ایران

ObjectivesAntiepileptic drugs are among the most common triggers of cutaneous adverse reactions. About 5–17% of epileptic patients develop idiosyncratic skin reactions at some point during their treatment course, most of which occur within the first two months of drug initiation. This study aimed to investigate the pattern of cutaneous drug reactions associated with anticonvulsant use among the pediatric population in Iran to identify high-risk individuals. Materials & MethodsIn this retrospective descriptive study, medical records of children aged two months to 14 years, who were diagnosed with drug reactions due to anticonvulsant drugs between April 2007 and March 2018, were reviewed, and relevant information were extracted. This multicenter study was conducted in several provinces of Iran.ResultsA total of 186 cases with a final diagnosis of the antiepileptic druginducederuption were evaluated. The median age of participants was36 months (range: 2-168), and 56% were male. In approximately70% of the children, phenobarbital was the culprit. The median timeinterval between initiation of the causative drug and development ofrash and fever was 10 and 7 days, respectively. The most commonrash type was maculopapular rash (69%). Overall, 33% of the patientsonly received antihistamines after discontinuation of the causativedrug. ConclusionSimilar to previously published studies in Iran, phenobarbital wasthe main cause of cutaneous drug reactions to antiepileptic drugs,indicating the necessity of paying more attention when prescribingphenobarbital for Iranian pediatrics.