Attention Deficit Disorder with Hyperactivity symptoms in early-treated phenylketonuria patients
نویسندگان
1 Department of Biology, Health and Social Sciences, Universidade do Sul de Santa Catarina (UNISUL) - Tubarão - Santa Catarina - Brazil
2 Department of Biology, Health and Social Sciences, Universidade do Sul de Santa Catarina (UNISUL) - Tubarão - Santa Catarina - Brazil
3 Department of Biology, Health and Social Sciences, Universidade do Sul de Santa Catarina (UNISUL) - Tubarão - Santa Catarina - Brazil
4 Department of Neurology - Hospital Santa Isabel - Blumenau - Santa Catarina - Brazil
5 Department of Pediatric Neurology - Universidade Federal de São Paulo (UNIFESP) - São Paulo - São Paulo - Brazil
6 Department of Biology, Health and Social Sciences, Universidade do Sul de Santa Catarina (UNISUL) - Tubarão - Santa Catarina - Brazil; Programa de Pós Graduação em Ciências da Saúde (PPGCS) - Laboratório de Pesquisa de Doenças Neurometabólicas - Universidade do Extremo Sul Catarinense (UNESC) - Criciúma - Santa Catarina - Brazil
7 Programa de Pós Graduação em Ciências da Saúde (PPGCS) - Laboratório de Pesquisa de Doenças Neurometabólicas - Universidade do Extremo Sul Catarinense (UNESC) - Criciúma - Santa Catarina - Brazil
doi
10.22037/ijcn.v14i1.18021چکیده
ObjectivesTo assess the presence of symptoms consistent with Attention Deficit Disorder with Hyperactivity (ADHD) in all patients with early-treated phenylketonuria (PKU) in the State ofSanta Catarina in southernBrazil.Materials & MethodsAll of the patients diagnosed with PKU by newborn-screening tests, with ages varying from 6 to 18 years and who started treatment before 60 days of life and presented phenylalanine levels consistently below 6 mg/dL throughout treatment, were included. The subjects were invited to complete a questionnaire that collected sociodemographic, gestational and clinical data. ADHD symptoms were assessed using the revision of the Swanson, Nolan and Pelham Questionnaire.Results: A total of 34 patients were evaluated, who were 53% male and 94% white and had an average age of 12 years, and 15% were born premature. According to the Swanson, Nolan and Pelham Questionnaire, 13 patients (38%) met the diagnostic criteria for ADHD, with 2 patients having the inattentive type, 6 patients having the hyperactive or impulsive type and 1 patient having the oppositional defiant disorder type.Conclusion:Although the patients with PKU were regularly treated from birth, there was a high prevalence of symptoms consistent with ADHD. A pathophysiological interface that involves the dopamine metabolic pathway may exist between the two conditions.
