Effect of growth hormone on muscle strength, tone and mobility of children with Prader-Willi syndrome
نویسندگان
1 Senior Researcher, Molecular Genetics, Department of Medical Genetics, Special Medical Center, Tehran, Iran
2 Assistant Professor of Human Genetics, Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
3 Pulmonologist, Tehran, Iran
4 Pediatric Neurologist, Tehran, Iran
5 Assistant Professor of Pediatric Endocrinology and Fellowship of Bone and Inherited Metabolic Disorders,Shahid Beheshti University of Medical Sciences, Tehan ,Iran
6 Assistant Professor of Pediatric Endocrinology, Tehran University of Medical Sciences, Tehran, Iran
7 Pediatric Neurologist, Tehran, Iran
8 Professor of Pediatric Endocrinology, Tehran University of Medical Sciences, Tehran, Iran
doi
10.22037/ijcn.v5i1.2121چکیده
ObjectivePrader-Willi Syndrome (PWS) is a genetic syndrome presenting with severe hypotonia and decreased agility. Growth Hormone (GH), which is often used in these patients to treat short stature and obesity, seems improve hypotonia, physical strength, activity, and locomotor developmental ability. The aim ofthis study was to find the effects of growth hormone on agility and strength of these patients.Material & MethodsIn a prospective randomized controlled clinical trial in an out-patient pediatric endocrine clinic in Tehran, 21 PWS children (12 boys and 9 girls, 4 to 9 years old) were divided into either GH-treated or control groups and followed for two years. Agility run, sit ups, weight lifting, and inspiratory and expiratory strength were considered as the main outcome measures.ResultsAll the outcome measures of the GH treated group showed a significant improvement compared to the control group.ConclusionGH causes a significant improvement in agility and strength of PWS children.Key words: Preder-willi syndrome; PWS; growth hormone;agility; strength
