Effect of Lamotrigine on Prophylaxis of Pediatric Classic Migraine
نویسندگان
1 Neurologist, Associate Professor Shahrekord University of Medical Sciences
2 Neurologist, Associate Professor, University of Welfare & Rehabilitation Sciences
3 Community Medicine Specialist, Associate Professor, Shahrekord University of Medical Sciences
4 Assistant Professor of Pediatric Department of Clinical Sciences Pediatric Neuro Rehabilitation Research Center, University of Welfare & Rehabilitation Sciences
5 Pharmacologist, Professor of Medical Plants Research Center Shahrekord University of Medical Sciences
doi
10.22037/ijcn.v3i2.1270چکیده
ObjectiveThis study was conducted to evaluate the preventive effect of lamotringine on migraine aura and migraine attacks in children, afflicted with classic migraine.Material & MethodsConducted between October 2005 and April 2008 in the neurology clinic of Kashani hospital, Shahrekord, this study was a clinical trial, aimed at evaluating the prophylactic effects of Lamotringine administered to 21 children suffering from migraine with aura.ResultsOf the subjects, 52.4% of patients were female. The most common type of aura was visual (42.9%). Following use of Lamotrigine, significant reductions were seen in the frequency (from 5 ± 0.83 to 3.04 ± 1.65) and in intensity (from 6. 33 ± 1.08 to 3.66 ± 1.1) of migraine aura (P= 0.002). After 6 months of drug usage 66.6% of patients were improved.ConclusionLamotringine is effective in reducing the migraine aura and intensity of attacks in patients suffering from migraine with aura, and is hence beneficial for prophylactic therapy in children with classic migraine.
