Protective Effects of Nano-Propolis Liposomes on Iischemia-Reperfusion Injury: A Rat Model of Testicular Torsion and Detorsion
نویسندگان
1 Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
2 Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
3 Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
4 Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
doi
10.30500/ivsa.2025.548473.1467چکیده
A rat testis model was used to assess the effects of nano-propolis liposomes on ischemia-reperfusion injury. Twenty-four healthy male Wistar rats were included and randomised into six investigational groups (n = 6): Group SHAM: only laparotomy was implemented. Group ISCHEMIA: only a 3-hour ischemia was induced. Group IS/REP: A 3-hour ischemia followed by 3 hours reperfusion for the left testis and one week reperfusion for the right testis was performed with 1 ml normal saline that was gavaged 1 hour before the onset of ischemia. Group IS/REP/NPL: As in group IS/REP, but with 1 ml nano-propolis liposomes gavaged 1 hour before the onset of ischemia. Evaluations were based on biochemical analyses and sperm parameters. Propolis enhanced antioxidant activity and quality of sperm parameters (p < 0.05). Nano-propolis liposomes could help minimize ischemia-reperfusion injury in testicular tissue exposed to ischemia.
