The Effect of Aerobic Exercise on Insulin Resistance: Narrative review of the Molecular Mechanisms

نویسندگان

1 Department of Exercise Physiology, CT.C, Islamic Azad University, Tehran, Iran.

2 Department of Exercise Physiology, CT.C., Islamic Azad University, Tehran, Iran.

3 Department of Exercise Physiology, CT.C, Islamic Azad University, Tehran, Iran.

4 Department of Physical Education and Sport Sciences, mah.c., Islamic Azad University, Mahabad, Iran.

5 Department of Physical Education and Sport Sciences, P.C., Islamic Azad University, Pardis Iran.

doi
10.18502/ijdo.v18i2.21650
چکیده

Insulin resistance (IR) is a central pathophysiological hallmark of type 2 diabetes mellitus (T2D) and related cardio-metabolic disorders. This narrative review explores the impact of regular physical activity, particularly aerobic and resistance exercise, on the mitigation of IR through various molecular mechanisms. Genetic predispositions, chronic low-grade inflammation, dysregulated circulating metabolites, hormonal imbalances, ...