Antibody Engineering to Enhancement of Ranibizumab Binding Affinity for the Prevention and Treatment of Diabetic Retinopathy

نویسندگان
Azamirad, Ghasem ID 1
Vahidi Mehrjardi, Mohammad Yahya ID 2
Sefid, Fateme ID 3
Monshizadeh, Kimia ID 4

1 Department of Mechanical Engineering, Yazd University, Yazd, Iran.

2 Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

3 Department of Medical Genetics, Shahid Sadoughi University of Medical Science, Yazd, Iran

4 Department of Medical Genetics, Shahid Sadoughi University of Medical Science, Yazd, Iran

doi
10.18502/ijdo.v16i2.15710
چکیده

Objective: The VEGF function blockage effectively reduces the progression of diabetic retinopathy. Ranibizumab and bevacizumab are some anti-VEGF monoclonal antibodies (mAb). Considering the importance of affinity maturation of ranibizumab, we aimed to find the essential amino acids of the ranibizumab antibody (Ab). Materials and Methods: We tried to find the ...

کلیدواژه‌ها
Antibody engineering, Anti-VEGF-A, Bioinformatic, Binding affinity, Ranibizumab