Pharmacokinetic Drug Food Interaction Study of Nateglinide and Pomegranate Fruit Juice
نویسندگان
1 Department of Pharmacology, Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, Maharashtra, India
2 Wockhardt Research Center, D-4, Chikalthana, Aurangabad, Maharashtra, India
3 Department of Pharmacology, Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, Maharashtra, India
4 Wockhardt Research Center, D-4, Chikalthana, Aurangabad, Maharashtra, India
doi
10.18502/ijdo.v12i4.5181چکیده
Objective: Pomegranate juice is inhibitor of CYP450 enzyme system such as CYP2C9 and CYP3A4. The objective of the present study was to determine the consequence of pomegranate fruit juice on the pharmacokinetics of oral hypoglycemic drug nateglinide in rats. Materials and Methods: This is a laboratory study to investigate drug-food interaction ...
