Genetics of Type 2 Diabetes- A Review Article

نویسندگان
Shahvazian, Ensieh ID 1
Sheikhha, Mohammad Hasan ID 2
Rahmanian, Masoud ID 3
Farashahi Yazd, Ehsan ID 4

1 Department of Genetics, Faculty of Medicine, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Clinical and Research center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

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چکیده

Objective: Type 2 diabetes (T2D) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. Linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. However, they were largely unsuccessful while applying to the more common forms of disease. ...

کلیدواژه‌ها
Genome Wide Association Studies, T2D, Insulin resistance, High blood glucose, Re-sequencing