Antibiotics at the crossroads – Do we have any therapeutic alternatives to control the emergence and spread of antimicrobial resistance?
نویسندگان
1 Department of Microbiology, College of Medicine and Health Sciences, National University of Science and Technology, Sohar Campus, Sohar, Sultanate of Oman
2 Department of Community Medicine, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India
3 Department of Microbiology, College of Medicine and Health Sciences, National University of Science and Technology, Sohar Campus, Sohar, Sultanate of Oman
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چکیده
Antibiotics once regarded as magic bullets are no more considered so. Overuse of antibiotics inhumans, agriculture, and animal husbandry has resulted in the emergence of a wide range ofmultidrug‑resistant (MDR) pathogens which are difficult to treat. Antimicrobial resistance (AMR)is a serious global health problem associated with high mortality in the era of modern medicine.Moreover, in the absence of an effective antibiotic, medical and surgical interventions can highlybecome a risk. In recent times, the decreased incline of pharmaceutical industries toward researchand development of newer effective antibiotics to fight this MDR pathogens have further fuelledthe scarcity of antibiotics, thus the number of antibiotics in the pipeline is extremely limited. Henceit is high time for the development of new strategies to fight against dangerous MDR pathogens.Currently, several novel approaches explored by scientists have shown promising results pertainingto their antimicrobial activity against pathogens. In this article, the authors have summarized variousnovel therapeutic options explored to contain AMR with special attention to the mechanism of action,advantages, and disadvantages of different approaches.
