A comprehensive in silico analysis of pathogenic nsSNPs in the NT5C2 gene involved in relapsed ALL

نویسندگان
Tajdini, Roxana ID 1
Chamani, Reyhane ID 2
Pourhesseini MahmoudAbadi, Parnia Sadat ID 3
Janati, Yasamin ID 4

1 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

2 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

3 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

4 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

doi
10.18502/ijpho.v12i4.10915
چکیده

Background: About 10-20% of children suffering from acute lymphoblastic leukemia (ALL), experience a relapse, which is a major cause of their death. Purine nucleotide analogs are frequently prescribed to maintain the treatment of ALL. Cytosolic 5´-nucleotidase (NT5C2) catalyzes the 5´ dephosphorylation of purine analogs. Gain-of-function mutations in the NT5C2 gene result in ...

کلیدواژه‌ها
Bioinformatics tools, NT5C2 gene, 5´-nucleotidase, Pathogenicity prediction, Relapsed ALL