Study of Gene Expression Signatures for the Diagnosis of Pediatric Acute Lymphoblastic Leukemia (ALL) Through Gene Expression Array Analyses

نویسندگان
Sheykhhasan, Mohsen ID 1
Fattahi, Abbas ID 2
Bouraghi, Hamid ID 3
Eghbalian, Fatemeh ID 4
Manoochehri, Hamed ID 5
Raeisi, Roya ID 6
Tanzadehpanah, Hamid ID 7

1 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

2 Department of Medical Library and Information Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.

3 Department of Health Information Technology, School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran

4 Department of Pediatrics, School of Medicine, Besat Hospital, Hamadan, Iran.

5 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

6 Department of Pediatrics, School of Medicine, Besat Hospital, Hamadan, Iran

7 Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

doi
10.18502/ijpho.v13i1.11630
چکیده

Background: Acute lymphoblastic leukemia (ALL) as the most common malignancy in children is associated with high mortality and significant relapse. Currently, the non-invasive diagnosis of pediatric ALL is a main challenge in the early detection of patients. In the present study, a systems biology approach was used through network-based analysis to identify ...

کلیدواژه‌ها
Acute lymphoid leukemia, Gene cluster, Gene ontology, Protein-protein interaction network, Survival analysis